TSRHC

Research

Division of Molecular Genetics

The Molecular Genetics program is dedicated to understanding the molecular causes and risk factors for targeted pediatric orthopedic disorders.

Meet Our Team


Carol Wise, Ph.D.
Director, Principal Investigator


Jonathan Rios, Ph.D.
Principal Investigator

Dongping Zhang, M.D., M.S.
Research Scientist

Xiaochong Gao
Research Scientist


January Brandon
Clinical Research Coordinator II


Kristen Mauldin
Research Coordinator


Anas Khanshour, Ph.D.
Postdoctoral Fellow


Nandina Paria, Ph.D.
Research Scientist

 

Areas of Investigation

Genetics of Scoliosis

We are currently applying large-scale methods that integrate clinical and genetic data to identify the molecular mechanisms behind scoliosis, the most common spinal deformity in children. Our current study is funded primarily by the National Institutes of Health and will involve more than 3,000 individuals with scoliosis and their families. This is a collaborative effort with other U.S. pediatric orthopaedic surgeons.

Genetics of Pediatric Inflammatory Diseases

Arthritis in children is not only painful and debilitating but can lead to permanent joint destruction. We previously identified the gene responsible for a type of severe childhood arthritis known as PAPA syndrome. We are currently participating in collaborative studies of this and other forms of juvenile arthritis.

Genomics Of Orthopedic Disease

The G.O.O.D. for Kids Program

The GOOD for Kids Program uses state-of-the-art research methods to discover genetic causes of skeletal growth disorders through close collaboration between the Division of Molecular Genetics and TSRHC physicians. One example is the group of disorders abbreviated as MOPD, the so-called “smallest people in the world.” In collaboration with the skeletal dysplasia program at the Nemours/Alfred I. duPont Hospital for Children and the Potentials Foundation, we are studying correlation between genetics and clinical presentation of these diseases.

The GOOD for Kids Program includes patients with numerous orthopaedic conditions treated at TSRHC physicians and collaborators world-wide.

You Can Help!

Enrollment is ongoing for TSRHC's genetic studies. You may be eligible to participate if you…

  1. are a TSRHC patient,
  2. have BEEN a TSRHC patient, or
  3. are interested in serving as a healthy control.

Please call (214) 559-7869 or (800) 421-1121, ext. 7869.